Modus Operandi - Poisoning

John Reginald Halliday Christie became one of the United Kingdom's most infamous serial killers after murdering multiple women, including his wife, at his home in Notting Hill, London, during the 1940s and early 1950s. His crimes, committed at 10 Rillington Place, led to one of Britain's greatest miscarriages of justice when Timothy Evans was wrongly convicted and executed before Christie's guilt was uncovered. The case remains one of the most significant in British criminal history.

Kouri Richins became one of the most heavily discussed true crime defendants in the United States after prosecutors accused the Utah mother and real estate investor of murdering her husband, Eric Richins, with a fatal dose of fentanyl in 2022. The case exploded into national headlines after investigators revealed that Richins later published a children’s book about grief dedicated to helping children cope with the death of a parent, creating widespread public fascination and intense media scrutiny. Prosecutors alleged the killing was financially motivated and tied to marital conflict, property disputes, and life insurance concerns. The investigation quickly expanded beyond the poisoning allegations and into Richins’ business dealings, finances, deleted communications, and alleged attempts to obtain fentanyl before her husband’s death. The combination of an affluent family image, children’s grief book promotion, and accusations of secret financial pressure turned the case into a major modern true crime story followed closely across television, podcasts, social media, and online crime communities.

Herman Webster Mudgett, better known as H.H. Holmes, became one of America's earliest infamous serial killers after carrying out a series of murders during the late nineteenth century. Operating from a specially designed building in Chicago that later became known as the "Murder Castle," Holmes used deception, fraud, and false identities to lure victims. Although he confessed to 27 murders before his execution, historians believe the true number of victims remains uncertain. His case remains one of the most famous in American criminal history.

Michael Swango became one of the most notorious medical serial killers in American history after being linked to a series of poisonings involving patients, coworkers, and acquaintances over several decades. A licensed physician and former paramedic, Swango exploited positions within hospitals and medical institutions to gain access to vulnerable victims while maintaining the outward image of a highly educated healthcare professional. The case generated international attention because Swango continued obtaining medical employment despite repeated suspicions, disciplinary actions, and criminal convictions. Investigators later connected him to deaths and poisonings across the United States and Africa, leading many experts to believe the true number of victims may never be fully known. His ability to repeatedly evade detection turned the case into one of the most disturbing examples of institutional failure and medical predation in modern criminal history.

Erin Patterson became one of Australia’s most internationally discussed accused killers after allegedly poisoning multiple family members with deadly mushrooms during a lunch gathering in regional Victoria in 2023. The case generated extraordinary worldwide attention because of the unusual alleged murder method, the family dynamics involved and the mystery surrounding whether the poisonings were deliberate. The investigation rapidly became one of the biggest true crime stories in Australia, attracting nonstop media coverage, internet speculation and global fascination. The combination of toxicology evidence, alleged deception, suspicious behavior and courtroom developments transformed the case into one of the most discussed criminal prosecutions of the decade.

Harold Frederick Shipman became one of the most prolific serial killers in modern history after murdering patients under his care while working as a general practitioner in England. Convicted of 15 murders in 2000, a subsequent public inquiry concluded he had likely killed at least 215 patients, with some estimates suggesting the true total exceeded 250. Shipman's abuse of trust, combined with the enormous scale of his crimes, fundamentally changed patient safety, death certification, and medical oversight throughout the United Kingdom.

James Toliver Craig, an Aurora, Colorado, dentist, murdered his wife of 23 years, Angela Craig, by poisoning her over a ten-day period in March 2023. Prosecutors established that Craig secretly obtained arsenic, cyanide and tetrahydrozoline while Angela repeatedly became seriously ill and required hospital treatment, ultimately administering a fatal dose of cyanide while she was hospitalised. Investigators uncovered internet searches about lethal and difficult-to-detect poisons, financial difficulties and extramarital affairs, while Craig later attempted to manufacture evidence supporting a suicide narrative and solicited the murder of the lead detective. A jury convicted him of first-degree murder and five solicitation charges in July 2025, and he was sentenced to life imprisonment without the possibility of parole.

Carol Ann Kopenkoskey is an American woman convicted of the 2012 murder of her husband in Michigan. The case involved a long-term marriage that ended in a planned domestic killing carried out in a secluded location. She later pleaded guilty to second-degree murder and was sentenced to a lengthy prison term.