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An eight-year search continues for Madeleine McCann, the British toddler who vanished in Portugal. A fresh investigation into her disappearance, part of "48 Hours" coverage, seeks to address unresolved aspects of the case.

A 35-year-old therapist and mother, Brooke Hanlon, was found stabbed to death in her Morris County, New Jersey, home after a 911 call reported blood everywhere. Authorities are searching for the suspect, with investigators withholding details about the case.

Firefighters in Buffalo discovered the bodies of 31-year-old mother Kathleen Carrig and her 4-day-old son in a house fire, which investigators linked to a cover-up for her homicide. Her boyfriend, Kidane Haile, faces second-degree murder charges, while authorities probe Noah’s death.

Authorities have released updated photos of Travis Decker, a 32-year-old sought for the murders of his three young daughters, noting he may have changed his appearance. The third-week investigation involves multiple agencies, ground and aerial searches, and analysis of lab results and crime scene evidence.

Houston officials are addressing a serial killer crisis, with at least 16 bodies recovered from bayous in the past year and up to 23 in Harris County. The investigation reveals authorities have been reluctant to disclose full details.

Ruth Miller, an Amish mother from Ohio, faces multiple charges, including aggravated murder, after allegedly drowning her 4-year-old son in a lake as a religious offering and driving a golf cart with her other children into water during a ritual. Her husband also died in an act tied to their religious practices. Miller has pleaded not guilty by reason of insanity, with her next court appearance scheduled for September 25.

Andrew James McGann, a former elementary school teacher, is accused of fatally stabbing parents Cristen and Clinton Brink during a hike in Devil’s Den State Park, Arkansas. Police describe the attack as random and unprovoked. Surveillance shows him being arrested mid-haircut, with DNA evidence and a matching vehicle linking him to the scene. McGann, employed by five school districts since 2022, faces two counts of capital murder, with prosecutors considering the death penalty after allegations of past inappropriate behavior.

Brian Hooker is in Bahamian custody after claiming his wife, Lynette, fell overboard during rough seas. Newly revealed messages detail his account of the incident, though inconsistencies and his inability to continue searching have raised questions. His stepdaughter cites past domestic violence allegations, prompting investigators to assess whether the disappearance was accidental or intentional.

Police investigate Domingo and Jessica Quintana’s Texas mansion after an alleged near-drowning incident involving their three children. Domingo claimed he rescued them from a pond, but child protective services took custody of the children, who reportedly avoided discussing their father. No charges were filed for the drowning, but Domingo was arrested for animal cruelty, and both parents face scrutiny over financial and legal history.

Karmelo Anthony faces first-degree murder charges for fatally stabbing Austin Metcalf. Authorities allege he instigated the altercation, while he claims self-defense. Police report he admitted to the killing, though witnesses dispute his account.

"48 Hours" investigates complex crimes, focusing on cases like Aileen Seiden's murder, the Depraved Heart Murder, and Alex Pennig's shooting. Since 1988, the series has aided in exonerating the wrongfully convicted, reopening cold cases, and influencing justice outcomes.

A 43-year-old Illinois woman, Robyn Polston, faces charges of criminal sexual assault and child pornography after DNA evidence linked her infant son to a 14-year-old boy. Investigators found she used burner phones and explicit images to communicate with the teenager, who she previously chaperoned. Despite a judge’s order for jail due to flight risk, she pleaded not guilty and is set for a January court appearance.